Genetic neurological disorder\Epilepsy and Seizures
SCIE.11.52
IN VIVO CROSS-CORRECTION ENHANCES THE EFFICACY OF GENE THERAPY IN A MOUSE MODEL OF CDKL5 DEFICIENCY DISORDER

Medici G. * [1] , Tassinari M. [1] , Galvani G. [1] , Gennaccaro L. [1] , Loi M. [1] , Mottolese N. [1] , Candini G. [1] , Giustetto M. [2] , Pizzorusso T. [3] , Hiroyuki N. [4] , Trazzi S. [1] , Ciani E. [1]

Bologna [1] , Torino [2] , Firenze [3] , Portland [4]
SCIE.11.54
CHARACTERIZATION OF THE GUT MICROBIOTA IN CDKL5 DEFICIENCY DISORDER TO REVEAL NOVEL BIOMARKERS AND THERAPEUTIC STRATEGIES

Xynomilakis O. [1] , Damiani F. [1] , Ottaviano E. [2] , Putignano E. [1] , Cornuti S. [1] , Tognozzi A. [1] , Pizzorusso T. [1] , Vignoli A. [2] , Borghi E. [2] , Tognini P. * [1]

Pisa [1] , Milan [2]
SCIE.05.58
NANOBODY-MEDIATED MODULATION OF HCN1 CHANNELS IN EPILEPTIC DISORDERS

Castelli R. * , Sharifzadeh A.S. , Leone R. , Giannini G.C. , Porro A. , Saponaro A. , Moroni A.

MILANO
SCIE.11.62
INTERACTION OF PRRT2 WITH NA+ CHANNELS: PATHOGENETIC BASIS AND NEW TARGETS FOR THE CURE OF PRRT2-ASSOCIATED PAROXYSMAL DISORDERS

Franchi F. , Sterlini B. , Corradi B. , Alberini G. , Ravasenga T. , Romei A. , Michetti C. , Maragliano L. , Baldelli P. , Corradi A. , Valente P. , Benfenati F. *

Genova
SCIE.11.55
INTEGRATED COMPUTATIONAL AND EXPERIMENTAL APPROACHES TO DRUG REPOSITIONING FOR RARE GENETIC DISORDERS

Di Bernardo D. , Criscuolo S. * , Failli M. , De Cegli R.

Napoli
SCIE.05.51
ANALYSIS OF INSYN1 FUNCTIONING IN THE REGULATION OF INHIBITORY NEURONAL TRANSMISSION IN A MOUSE MODEL OF CDKL5 DEFICIENCY DISORDER

Valetti G. , Baldin S. , De Rosa R. , Carmone C. , Lora C. , Valastro S. , Kilstrup-Nielsen C. , Barbiero I. *

Busto Arsizio
SCIE.16.61
CURE MERRF: FROM FIBROBLASTS TO ORGANOIDS SPEEDING BASIC SCIENCE INTO CLINICAL TRIALS FOR MITOCHONDRIAL DISEASES

Maresca A. * [1] , Capirossi G. [1] , Capristo M. [1] , Del Dotto V. [1] , Sacchetti G. [1] , Tropeano C.V. [1] , Pisano A. [2] , Giordano C. [2] , D'Amati G. [2] , Carelli V. [1]

Bologna [1] , Roma [2]
SCIE.11.57
TEMPORAL MANIPULATION OF SCN1A GENE EXPRESSION IN DRAVET SYNDROME

Salamone A. , Valassina N. , Brusco S. , Di Berardino C. , Mainardi M. , Becca M.V. , Broccoli V. , Colasante G. *

Milan
SCIE.11.59
NOVEL INSIGHTS ON CHLORIDE REGULATIONS: IMPLICATION FOR DISEASE ETIOLOGY AND TREATMENT

Marika A. [1] , Brondi M. [1] , Di Soccio A. [1] , Garavaldi T. [2] , Landi S. [2] , Nardi G. [2] , Pasquini G. [2] , Pracucci E. [2] , Lodovichi C. * [1] , Ratto G.M. [2]

Padova [1] , Pisa [2]
SCIE.11.60
RNA-BASED RESCUE OF INHIBITION AS POTENTIAL TREATMENT FOR GENETIC GABRA1-DEPENDENT EPILEPSY

Nencini S. * , Bruno M. , Stefania G. , Enrica P. , Andrea B.

Genova
SCIE.11.56
PCDH19-RELATED NEURODEVELOPMENTAL SYNDROME: UNRAVELING THE PLAYERS OF NEURONAL HYPEREXCITABILITY IN SEARCH OF NEW THERAPEUTIC TARGETS

Mazzoleni S. * [1] , Busnelli M. [1] , Piazza R.G. [2] , Bassani S. [1]

Vedano al Lambro [1] , Milano [2]
SCIE.05.53
UNVEILING THE FUNCTIONAL ROLE OF CDKL5 AT THE INHIBITORY SYNAPSE THROUGH ITS INTERACTION WITH THE CYTOPLASMATIC COLLYBISTIN-GEPHYRIN COMPLEX

De Rosa R. * , Valastro S. , Lora C. , Randi S. , Barbiero I. , Baldin S. , Carmone C. , Kilstrup-Nielsen C.

Busto Arsizio