This study examined whether pilots' levels of situation awareness (SA) and disposition to mindfulness, both general and piloting-specific, contribute to prospective memory (PM) performance during a simulated flight. A flight scenario was developed based on prior literature and expert consultation, incorporating episodic and habitual PM tasks. SA was assessed in line with Endsley's three-stage model: perception (SA1), comprehension (SA2), and projection (SA3). Using the Situation Awareness Global Assessment Technique (SAGAT), the flight was interrupted at two points, and participants responded to queries targeting each SA stage. Participants were 36 First Officers employed by commercial airlines. All flights were conducted in a Boeing 737 NG simulator, with an experienced pilot serving as captain. Following the simulations, participants completed self-report measures of general mindfulness, piloting-specific mindfulness, perceived workload, and demographic information. Hierarchical regression analyses, controlling for age, total flight hours, and workload, indicated that SA predicted PM task performance. More specifically, only the projection stage (SA3) significantly contributed to performance, and this effect was observed for episodic PM rather than habitual PM tasks. These findings suggest that higher-order anticipatory processes may be especially critical for managing complex, event-based demands in flight contexts. Qualitative data were collected from 12 randomly selected participants to identify factors influencing SA and PM performance. Two themes were common to both simulated and real flights: "Captain Pilot Issues" and "Operational Issues." In real flights, additional themes of "Individual Issues" and "Personal Issues" were identified, whereas an "Experiment Factor" emerged uniquely in the simulation context. Overall, the results underscore the role of SA, particularly projection, in supporting pilots' PM. These findings highlight the importance of prioritizing SA in pilot selection and training to enhance flight performance and safety.