Objective: Colombia has 23 million women, 50% of them are head of household mothers with vulnerabilities related to work access and an overload of work and family responsibilities. Thus, it is proposed to comprehend the head of the household mothers' meaning of life and self-fulfillment, who currently work in the health care sector at Subred Integrada de Servicios de Salud Centro Oriente (hospital network) of Bogotá, Colombia. Method: The biographical methods were used to obtain the life trajectories of seven participants regarding motherhood, being head of the household mothers, working in the health care sector and meaning of life. There were applied three biographical interviews per participant for a total of 21 interviews. The coding and interpretative analysis were triangulated among the researchers and external experts. Results: The participants acknowledged their motherhood reliant on being head of the household mothers regardless their family's composition. It is also reaffirmed that the motivations, objectives and projections of the participants' meaning of life change according to their vital cycles and courses. As an emerging result, it is found that caring is a continuity in their trajectories. This builds their meaning of life and allows a feeling of self-fulfillment. Conclusions: The findings suggest that the participants' meaning of life is built on caring for others and for themselves in family and work. Furthermore, being a head of household mother is a self-decision and does not make the participants vulnerable as it is perceived by society and Colombian legislation. Finally, working in the healthcare sector is a paradox because its precariousness, but is also an asset to learning and face difficulties in life situations. Thereby, the participants' permanence in a health care work allows for care as a structuring dimension of their meaning of life and self-fulfillment.