Objectives: To reduce vaccination hesitancy, it is important to know what type of interventions are effective. Interventions to lower vaccine hesitancy often have positive effects among people who hold a favorable attitude towards vaccination and more mixed effects among people who are hesitant about vaccination. One possible explanation is that typical interventions are generic and not tailored to the specific reason why a person is hesitant towards vaccination. The attitude-roots model proposes that interventions are more successful when tailored to the specific underlying cause or reason for a person's opposition. In this study, we tested this proposition by assessing whether a tailored information intervention is effective in increasing flu shot intentions. Methods: Participants (N = 1,021) rated 66 vaccination statements, reported their flu shot intentions at two time points, and were presented with either a tailored infographic, a generic infographic, or no infographic. Results: Flu shot intentions increased significantly after participants were presented with a tailored infographic, but this increase was not significantly greater than the increase observed among participants who were presented with the generic infographic or no infographic. Explorative analysis showed that tailoring might be more effective for some motivations (e.g., unwarranted beliefs) and not effective for others (e.g., religion). Conclusions: Overall, our findings showed mixed support for the effectiveness of a tailored infographics to increase flu shot intentions. This suggests that more research is needed to determine if and how tailored information interventions are a viable strategy to reduce vaccination hesitancy.