Backgrounds: Treatments for adolescent non-suicidal self-injury (NSSI) primarily focus on reducing self-injury behaviors directly, which remain limited in efficacy. Here we proposed an integrated intervention combining process-oriented and outcome-oriented perspectives. Methods: Study 1 conducted a chain mediating model that contains four variables including negative parenting, self-compassion, depression, and NSSI with 1829 adolescents. Based on this, the treatment effect of the self-compassion focused process-outcome integrated training (SCFIT) on 77 NSSI adolescents was investigated in study 2. Results: A chain mediating effect was found in study 1, and study 2 showed that compared with DBT-control group and waitlist, there were more considerable reductions in self-injury behaviors and depressive symptoms and significant improvements in self-compassion in the SCFIT group over the 8-week intervention, and the effects remained at 1-month follow-up. Conclusions: The SCFIT project effectively reduced adolescent NSSI through three aspects of blocking, repairing, and alleviating, and provided encouraging and comprehensive support for future NSSI treatment.