Purpose: The features characteristic of Borderline Personality (BPF) encompass instability in interpersonal relationships, self-perception, and emotional expression, with emotional dysregulation as a central component. This instability can lead to interpersonal challenges and an increased perception of burdensomeness (PB), where individuals view themselves as burdens to others. This perception is a recognized form of interpersonal stress and a significant predictor of depressive states. This study aims to clarify the relationship between BPF and depression, specifically investigating the sequential mediating effects of emotional dysregulation and perceived burdensomeness. Methods: A cohort of 339 participants, aged 18 to 30, was recruited for the study. Each participant completed the Personality Assessment Inventory - Borderline Features Scale (PAI-BOR), the Difficulties in Emotion Regulation Scale (DERS), the Interpersonal Needs Questionnaire (INQ), and the Beck Depression Inventory-II (BDI-II). Spearman's correlation analysis was employed to assess the interconnections between variables, while regression analysis was used to determine the predictive capacity of each variable. Additionally, mediation analyses were conducted to evaluate the mediating role of emotional dysregulation in the relationship between Borderline Personality Features and perceived burdensomeness, as well as the sequential mediation effects of emotional dysregulation and perceived burdensomeness in the relationship between Borderline Personality Features and depression. Results: The study produced four key findings: (1) BPF is a positive predictor of both PB and depression. (2) PB is a positive predictor of depression. (3) Emotional dysregulation acts as a mediator between BPF and PB. (4) Emotional dysregulation and PB sequentially mediate the relationship between BPF and depression. Conclusions: This research highlights the mediating roles of emotional dysregulation and perceived burdensomeness in the context of Borderline Personality Functioning (BPF) and depression, providing valuable insights into the mechanisms underlying the comorbidity of these conditions. Future longitudinal studies are recommended to further explore the causal pathways among these variables.