A growing body of scientific literature conceives psychopathy as a maladaptive variant of normal personality, reflecting the more general interest in understanding personality disorders from the five-factor model (FFM) or Big Five. Sanz-García et al. (2022) developed a psychopathy scale (known as EP-NEO for its name in Spanish) based on Costa and McCrae's (1992) NEO Personality Inventory Revised (NEO PI-R), the standard instrument for assessing the FFM. The aim of this presentation is to summarize the results of several studies conducted to examine the reliability and validity of EP-NEO scores in samples of adult volunteers from the general Spanish population (N = 682, 239, and 525). The EP-NEO presented a structure of three correlated factors (Interpersonal, Affective, and Lifestyle) similar to those of Hare's model of psychopathy underlying the PCL-R. Internal consistency coefficients were excellent for the total score (alpha/omega = 0.85-0.89) and between adequate and excellent for the scale scores (alpha/omega = 0.76-0.89). The convergent correlations with measures of antisocial personality disorder from the NEO PI-R (r = 0.88-0.96) and with the psychopathy measure from the SRP-4 (r = 0.76) were excellent and greater than the discriminant correlations with measures of other personality disorders from the NEO PI-R. These results suggest that the EP-NEO provides reliable and valid measures of psychopathy in Spanish adults assessed in situations where there is no direct interest in distorting responses.