Healthcare workers face unique and intense stressors stemming from long hours, high emotional demands, life-and-death decision-making, trauma exposure, and resource limitations. These factors can lead to chronic stress and burnout, affecting both personal well-being and professional performance. Understanding their experiences is essential for developing interventions that protect mental health and sustain high-quality care. Resilience, the ability to adapt, recover, and thrive amid adversity, is a vital protective factor. Far from being purely innate, resilience can be cultivated through personal strategies and supportive environments. Resilient healthcare workers maintain emotional stability, problem-solving capacity, and motivation even under pressure. This reduces burnout risk, enhances job satisfaction, and improves patient safety. Our systematic review examines the relationship between stress, resilience, and coping strategies in healthcare professionals. It highlights evidence-based approaches such as mindfulness, peer support, physical activity, healthy sleep, and clear professional boundaries. We followed PRISMA guidelines and included 27 studies in our review at the last stage. Organizational measures, including access to mental health services, workload adjustments, and open communication, are equally important in building systemic resilience. By addressing both individual coping skills and institutional support, this work underscores that resilience is not merely a wellness initiative but a strategic necessity. Supporting those who care for others strengthens the healthcare workforce and ensures the delivery of compassionate, high-quality care.