Little to no research has examined implications of perceptions of financial vulnerability among parents caring for a child with chronic congenital heart disease (CHD). These parents face enormous financial obligations associated with hefty healthcare costs and can result in a great deal of emotional strain, as evident in decreased interaction with family, lower well-being, and greater work-family conflict. One study thus far has shown that financial vulnerability due to healthcare costs adversely affects parents' well-being differently for dual-earner households compared to single-earner households (where the mother is primary caretaker and father works). Drawing on Conservation of Resources Theory, the current study examines whether meaningfulness in life (MIL) serves as a cognitive resource that prevents experiencing financial vulnerability and anxiety amongst working mothers in dual-earner households (n = 178). Findings show that despite increasing financial vulnerability, anxiety is consistently lower for mothers with high (vs. low) MIL, suggesting that MIL has a direct connection to both stressor and strain, but that it does not necessarily protect one from experiencing anxiety as financial strain increases. In other words, financial vulnerability positively relates with anxiety regardless of level of MIL. However, working mothers with high MIL consistently report less anxiety across all levels of financial vulnerability. Thus, MIL influences anxiety but does not alter the strength of the financial vulnerability-anxiety relationship. This finding is discussed theoretically and practically in terms of stress prevention theory.