Since it was coined after the Chernobyl nuclear catastrophe, safety culture has been one of the most studied topics within High Reliability Organizations (HROs). Recent research advances present a timely opportunity to integrate past and recent studies. This study will conduct a meta-analysis based on empirical studies of safety culture to investigate both its proximal and distal outcomes. Peer-reviewed articles published in the past 20 years will be retrieved from PsycINFO and ProQuest databases, analyzed and selected using the PRISMA method. The identified variables will be categorized as proximal or distal outcomes, depending on their contingent relationship with safety culture, and a general effect size for each of them will be assessed through a meta-analysis. Given the inherent methodological variability across studies, such as differences in intervention allocation, participant age ranges and randomization procedures, a random-effects meta-analysis will be applied (Deeks et al., 2019). This approach aims to minimize between-study variability, reduce bias introduced by different study designs, and provide more generalizable effect size estimates. Additionally, the random-effects model will adjust for variations in statistical techniques across studies, further improving the reliability of the results. This study expects to contribute to understanding the personal and contextual variables related to the development of safety culture, as well as the strength of these relationships