Cancer diagnosis and treatment can disrupt the pursuit of life goals that are hallmarks of young adulthood and enhance risk for immediate and longer-term physical and psychological adverse outcomes. Goal navigation skills, including the ability to clarify values and identify new and existing goals, might play a role in regulation of stress-sensitive biobehavioral factors, including inflammatory processes that are often associated with a host of physical and psychological symptoms. We developed Goal-focused Emotion-regulation Therapy (GET) to improve distress symptoms, emotion regulation, and goal navigation skills. GET is designed to improve distress symptoms, emotion regulation, and goal navigation skills, which would be expected to improve regulation of stress-sensitive biomarkers. This talk will present a series of studies to develop and establish the feasibility of GET in young adult men with testicular cancer, with a focus on a randomized trial evaluating the impact of GET on psychological, biological, and clinical outcomes relative to a time-matched control group. In this study, young adult men with testicular cancer who had undergone chemotherapy within the last two years were randomized to GET or individual supportive therapy (ISP) delivered over 8 weeks. Assessments were taken at baseline, post-intervention, and again 3-months later. This included stress and immune biomarker measurement. Then, results from a follow-up open trial with young adult Hispanic men with testicular will be presented with a focus on impact on psychological adjustment, inflammatory biomarkers, and epigenetic markers of self-regulation. Finally, future directions and current work, including studies of GET in other populations will be discussed. Despite the substantial adverse psychological impact of testicular cancer, few interventions have sought to improve psychosocial functioning and stress-related biomarkers in young adult survivors. GET, an intervention designed to promote goal-related and emotion-focused self-regulation, has potential to mitigate stress-related processes and inflammation in this young adult survivor group.