Extensive scholarly evidence suggests that individuals with higher levels of neuroticism tend to experience lower mental well-being. Individuals from diverse cultural backgrounds may interpret psychological constructs in varied ways. This study examines the relationship between neuroticism and mental well-being, and further investigates the mediating role of indulgence. The analysis is based on data gathered from the northern-central and southern regions of India, employing standardized measurement instruments such as the WEMWBS scale, Hofstede's Scale, and the Big Five Inventory (BFI). Data were analysed using AMOS software. Findings suggest that indulgence mediates the relationship between neuroticism and mental well-being. These results highlight the significance of cultural and personality variables in studies aimed at promoting mental well-being.