Goal 3 "Good Health and Well-being" of the Agenda 2030 for sustainable development, underscores their role as essential pillars of sustainable development. In the literature, career adaptability (Savickas & Porfeli, 2012) is positively associated with individual well-being, as it facilitates adaptive responses to career-related challenges and promotes psychological resilience during transitions. Within the framework of the psychology of sustainability and sustainable development, career adaptability emerges as a critical resource for promoting career sustainability. Sustainable development as the fourth paradigm for 21st century careers (Hartung & Di Fabio, 2024) also asks for adopting a broad, inclusive approach that respects nature (animals, plants, and the planet) considering the present and the future. In this framework, this contribution will present a systematic review conducted according to the PRISMA standards, considering Scopus, Web of Science, PubMed, and APA PsycArticles databases on career adaptability and well-being. The aim of the review was to systematize recent scientific evidence regarding relationships considering career adaptability and its four dimensions (concern, control, curiosity, confidence) and well-being and its two sides (hedonic and eudaimonic), both in life and at work. The selection and analysis have been taken from 584 records from the four databases. The findings of this systematic review will contribute to delineate future perspectives for research and intervention for sustainable development of careers in the 21st century and Goal number 3.