The pursuit of meaningful work has emerged as a pivotal concern for workers navigating an era of rapid technological change, economic instability, and sociopolitical turbulence. While meaningful work is consistently associated with positive outcomes such as engagement and well-being, its realization remains uneven, particularly among those facing systemic constraints. This study examines how white-collar professionals in Türkiye experience meaningful work, a context marked by weak education-employment linkages, limited perceptions of meritocracy, and rising political and economic uncertainties. Utilizing survey data from white-collar employees aged 18-59, the study tests a dual pathway model. The threat pathway proposes that technostress increases competence need frustration, undermines the experience of meaningful work, and thereby fuels hopelessness. The motivational pathway posits that job-related psychological resources strengthen autonomy need satisfaction, enhancing both meaningful work and meaning in life. Findings are expected to inform policymakers and organizational leaders seeking to support professionals' pursuit of meaningful work amidst profound existential, economic, and technological disruptions.