Neurotechnology has the potential to provide high-performance products and services, with its miniaturization and minimally invasiveness of devices, coupled with the development of artificial intelligence (AI) for processing, analyzing, and generating commands based on neural activity. One company predicts that the market size will reach approximately $52.9 billion by 2034. However, this technology, which enables the extraction, measurement and visualization of information on individual emotions and cognition from neural activity, has the potential to bring a paradigm shift in the field of applied psychology. Indeed, ethical concerns must be addressed, including the research participant protection in experiment using neurotechnology, ownership and privacy protection of information derived from neural activity, the potential physical and mental effects of long-term use, the prevention of dual use, misuse and malicious use of neurotechnology, and the possibility of unauthorized use in education, labor, and judicial settings without the individual's free consent. These concerns require the implementation of Responsible Research and Innovation (RRI) taking into account risk management. Based on such rationale, the research project "ELSCI and Governance as the Measures for the Era of Neurotechnology Native" funded by RInCA Program has conducted investigations by analyzing the ELSCI (ethical, legal, social, and cultural issues) of application of neurotechnologies and their impact on human cognition, behavior, and society, to support the development of domestic and international rules for the appropriate use and dissemination of neurotechnology with artificial intelligence (AI), as well as the establishment and operation of governance systems. In this presentation, the author will provide an overview of domestic and international efforts to establish rules and governance systems for human research using neurotechnology, and discuss the challenges and solutions to be considered, particularly at the R&D stage, and how these should be compatible with the sound development of psychological research including neuroscientific procedures.