In the era of digital transformation and Industry 4.0 and 5.0, IT professionals are confronted with increasing cognitive and emotional demands. Soft skills have emerged as key determinants not only for technical performance but also for mental health; however, their relationship with psycho-emotional symptoms remains poorly understood. This study aimed to investigate the correlation between soft skills and psycho-emotional aspects among professionals at a Brazilian technology development organization. A cross-sectional study was conducted between November and December 2024, involving 114 employees who completed an online questionnaire comprising 30 items assessing soft skills and 13 psycho-emotional aspects, all evaluated on a Likert scale. Descriptive analysis was performed to characterize the sample, social skills, and psycho-emotional symptoms. The soft skills with the highest positive prevalence were commitment/engagement, responsibility, and persistence. The most frequent symptoms identified were anxiety, impostor syndrome, and knowledge insecurity. Significant correlations were observed, notably between proactivity and knowledge insecurity; time management and both lack of concentration and knowledge insecurity; self-awareness/conscientiousness and lack of concentration; leadership and knowledge insecurity; innovation and knowledge insecurity; and passion and symptoms of depression. The results indicate that professionals with higher levels of soft skills also exhibit higher levels of psychological well-being. These findings underscore the importance of programs aimed at balanced development of interpersonal and emotional skills to promote mental health and optimize performance in the IT sector.