Sustaining long-term science-policy initiatives requires strategic resource mobilization to ensure continuity and maximize impact. Evidence from large, integrated funding programs—or lighthouse programs—shows that interdisciplinary collaboration and policy engagement can foster sustainable development and strengthen science-society-policy connections. Yet without funding models that prioritize stakeholder-engaged research, science remains underutilized in addressing real-world challenges. This presentation introduces ComPASS-PR's contextual model for sustainability, designed to support structural health equity initiatives in Puerto Rico. The strategy combines multiple mechanisms: hiring a leveraging analyst to identify and coordinate funding opportunities; strengthening institutional partnerships; cultivating corporate and private sector buy-in; investing in key personnel; expanding private funding streams; and securing five new projects annually. Additional initiatives include launching new products to increase program visibility and negotiating the federal indirect cost rate to reinforce institutional resilience. Framed within the Mission Science for Sustainability approach, which emphasizes co-produced and actionable knowledge for long-term impact, the strategy actively integrates policy and societal actors into the design and implementation of solutions. This reframing moves beyond Global North-centric sustainability models by emphasizing context-specific approaches shaped by Puerto Rico's history, socio-economic realities, and community priorities. Preliminary outcomes highlight the importance of increasing indirect funding capacity, enhancing staff training, and upgrading technology to ensure continuity. Challenges include limited philanthropic ecosystems and navigating compliance requirements, while opportunities emerge from cross-sector partnerships and new project pipelines. Ultimately, a contextual sustainability model is essential for advancing equity-driven, community-engaged science-policy initiatives in Puerto Rico and offers a replicable framework for other regions facing similar structural challenges.