Spirituality serves as a huge source of strength and resilience, when parents must confront a diagnosis of paediatric cancer. The unpredictable trajectory of paediatric cancer can contribute to huge levels of anxiety, depression and fear which can exacerbate the physical and mental health of the child and parents alike. This paper explores the role of spirituality through the lens of parents and mental health professionals, with a particular view, to understanding how paediatric cancer impacted the emotional well-being of parents, but more importantly to understand how spiritual practices can be used to support their psychological well-being. Although seemingly silent spirituality has a huge influence on psychotherapy, as spirituality can be particularly beneficial for families managing the mental health sequelae of anxiety, fear and depression, which is linked to a child with cancer. Using a qualitative case study design, this study sought to understand the mental health effects of paediatric cancer on children and their parents and how spirituality was used to support their coping and well-being as they transitioned through the complexities of treatment and recovery related to childhood cancer. Interviews were held with twelve parents and ten psychologists and social workers to understand how spirituality had benefitted paediatric cancer patients and their families. The interviews were audio-recorded, transcribed verbatim and analysed to develop major themes and subthemes by inductive and constant comparison. Four themes were identified namely, the mental health impact of cancer on the child and family, seeking peace and strength through spirituality, the integration of spirituality into psychotherapeutic practice; connecting with spiritually based interventions to heal and transcend the struggle with cancer. The study found that spiritually based practices such as mindfulness meditation, and other religious rituals were hugely therapeutic for both the child and their family providing comfort and hope.