Aging is an inevitable biological process characterized by progressive physiological, cognitive, and psychological changes that can compromise individuals' health, autonomy, and quality of life. While aging is often accompanied by increased vulnerability to chronic diseases, cognitive decline, and psychosocial challenges, recent advances in gerontology have shifted the focus from merely extending lifespan to enhancing health span, the period of life spent in good health. This research aims to comprehensively understand the multifaceted impact of aging and develop evidence-based intervention strategies to mitigate its adverse effects across biological, psychological, and social dimensions. A mixed-methods approach was used to integrate findings of quantitative biomarkers (e.g., inflammatory markers, epigenetic clocks) with findings based on qualitative assessments (e.g., personal narratives, psychological scales) to capture a holistic view of aging in diverse populations. The focus was maintained on given to the role of psychosocial factors such as loneliness, age-related stereotypes, socioeconomic status, and cognitive resilience. These interventions span five key domains: (1) Senolytic and regenerative therapies targeting cellular aging; (2) Cognitive training and neuroplasticity exercises to slow cognitive decline; (3) Socioemotional interventions, including reminiscence therapy and intergenerational programs, to improve mental health and social integration; (4) Technology-assisted supports, such as wearable health monitors and AI-driven companionship tools; and (5) Lifestyle modifications emphasizing nutrition, physical activity, and stress reduction through mindfulness-based interventions. Preliminary findings suggest that multifactorial and personalized intervention approaches significantly outperform traditional one-size-fits-all models in promoting resilience, autonomy, and well-being among older adults. For instance, participants in personalized cognitive training programs demonstrated slower cognitive decline and greater emotional regulation over a 12-month period, while those engaged in structured reminiscence therapy reported improved mood and social engagement. By addressing aging as a biopsychosocial phenomenon, the study highlights the importance of early intervention and community-based support systems.