Psychological health in the workplace is widely recognized as a fundamental determinant of job satisfaction, organizational engagement, and overall quality of life (Schaufeli & Bakker, 2004; Bakker et al., 2016; Upadyaya et al., 2016). For employees with disabilities, work is not only a source of income but also a critical dimension of social inclusion and identity (Akkerman et al., 2018). Previous research among employees with disabilities has highlighted that they experience both generic demands (e.g., workload, time pressure) and disability-specific stressors (work environment barriers), while valuing resources such as supportive social relations and inclusive work climate (Efimov et al., 2022; Flores et al., 2021; Tuan et al., 2021; Ybema et al., 2020). Consistent with the Job Demands-Resources (JD-R) Theory (Bakker & Demerouti, 2017; Bakker et al., 2023), high demands and limited resources predict burnout, whereas resources foster engagement and psychological health (Kordsmeyer et al., 2022; Bakker & Demerouti, 2023). Building on this theoretical framework, the present study aims to identify both general and disability-specific factors that influence well-being and burnout among employees with physical disabilities working in the Moroccan public sector. Results show that these workers are exposed to various job demands, including workload, discrimination, and physical work environment. Moreover, the findings reveal that an inclusive work environment, job autonomy, social support, recognition and appreciation of skills have been the most significant resources promoting well-being of workers with physical disabilities. In line with previous research, the present findings emphasize the importance of the work context in order to enhance psychological health and well-being of workers with physical disabilities (Alcover & al., 2018; Flores & al., 2011; Li & al., 2015). Theoretical and practical implications, limitations of the study and recommendations for improving the well-being of workers with disabilities will also be discussed during the conference.