The temporal intersectional minority stress model describes how social and legal contexts influences the unique experiences of minority stress among LGBTQ+ people (Rivas-Koehl et al., 2023). The negative psychological effects of minority stress may be exacerbated by sociopolitical hostility toward LGBTQ+ people, such as during the 2025 presidential administration in the United States of American (USA). Moreover, there is limited research on the link between sociopolitical stress during the 2025 presidential administration in the USA, as well as on how this association may differ across different minoritized groups. To address these gaps, this study aimed to explore the relationship between sociopolitical stress under the 2025 presidential administration in the USA and three mental health outcomes (i.e., psychological well-being, depression, anxiety) in 470 LGBTQ+ young adults (Mage = 21.9), as moderated by three sociodemographic factors: gender identity (cisgender vs. transgender and gender diverse), sexual identity (monosexual vs. plurisexual), and racial group (does not identify as a person of color vs. identifies as a person of color). Findings show that higher sociopolitical stress was associated with poorer mental health outcomes, and only gender identity moderated this association: the positive association between sociopolitical stress and mental health problems was higher for gender diverse participants compared to cisgender participants. Findings emphasize the importance of contextualizing minority stress against LGBTQ+ people within broader sociopolitical contexts and suggest that interventions with this population should acknowledge the external origins of sociopolitical distress. Findings from this study could be used by clinicians to target multiple sources of resilience (e.g., personal resilience, affirming social support networks, collective action) that may buffer against stressful sociopolitical experiences. Finaly, findings provide some guidance for policymakers on how to best advocate for LGBTQ+ people during hostile sociopolitical climates.