An increasing proportion of the population is prone to "vulnerable work" or 'precarious work that places people at risk of continuing poverty and injustice resulting from an imbalance of power in the employer-work relationship.' Understanding the experiences of vulnerable workers has recently emerged as a research priority. By definition, these workers' circumstances exacerbate the possibility of negative mental and physical health, vocational, and personal outcomes, which highlights the practical significance of this research. However, vulnerable workers may experience barriers to participation in research and be more prone to coercion or exploitation in research contexts than those in less vulnerable circumstances and this research can present unique challenges for researchers including the emotional toll associated with gaining participants' trust and being privy to difficult stories. To articulate practical recommendations for conducting research with vulnerable workers, we integrate principles from philosophy of science, community-based research methodologies, and feminist perspectives. Specifically, we present pragmatism as a paradigmatic approach to conducting this research and propose a number of methodological best practices grounded in this approach. Pragmatism is a particular form of inquiry in which its effectiveness is determined by its ability to meet its intended goals and the practical usefulness of its outcomes. We outline how pragmatism aligns with many of the principles associated with ethical, mindful research with vulnerable populations and discuss several "pragmatic" best practices for engaging in this type of research. In doing so, we link philosophy to practice, and suggest that pragmatism presents an opportunity to think about the process of research in terms of its practical outputs—which is of key importance to any research conducted among the vulnerable workforce. A cornerstone of building trust with vulnerable workers is conducting research in ethical, responsible, inclusive, and sustainable ways.