In a romantic relationship is associated with greater overall well-being compared to being single. High-quality relationships promote subjective well-being and reduce negative affect and loneliness. Moreover, they foster fundamental psychological elements such as intimacy, emotional connection, and mutual social support. These factors contribute to other domains of psychological well-being: realization of personal and shared goals, as well as autonomy, competence, and relatedness within the partnership (Gómez-López et al., 2019). The objective of this study was to determine whether there are statistically significant differences across the five domains of well-being according to PERMA theory (Seligman, 2014) between individuals in romantic relationships and those who are single. A sample of 86 Mexican adults (40% women, 60% men; mean age = 34.54 years, range = 18-70, SD = 11.72) participated. Fifty-three point forty-nine percent reported being in a romantic relationship, while 46.51% identified as single. Sampling was non-random and conducted via convenience sampling. Well-being was assessed using the PERMA-Profiler scale (ω = .935) (Butler & Kern, 2016): positive emotions (ω = .914), engagement (ω = .570), positive relationships (ω = .725), meaning in life (ω = .935), and accomplishment (ω = .859). Results revealed statistically significant differences in positive emotions (U = 608.00, z = -2.126, p = .033), positive relationships (U = 550.00, z = -2.795, p = .005), meaning in life (U = 633.50, z = -2.194, p = .028), and accomplishment (U = 573.50, z = -2.449, p = .014), with higher scores observed among individuals in romantic relationships. No significant differences were found in the domain of engagement. Findings are discussed in terms of how romantic partnerships may contribute to well-being across distinct domains. It should be noted that the quality of the romantic relationship was not evaluated in this study. This work was supported by UNAM-PAPIIT IN301225.