The meta-analysis by Hu et al. (2025) identified six mental health issues among individuals with HIV: depression, anxiety, suicidal ideation, posttraumatic stress disorder, stigma, and psychological distress. Tesfaye et al. (2014) reported that patients with HIV who experience low social support are 23.5 times more likely to exhibit psychological distress. The quality of social relationships constitutes a fundamental component of social support. Thus, this study aimed to determine whether, in a sample of patients with HIV, the perception of positive social relationships is significantly associated with lower levels of negative-valence emotions and greater subjective perception of happiness, as indicators of psychological well-being. A total of 227 Mexican patients with HIV participated, with a mean age of 34.94 years (Range = 18-63, SD = 8.88), predominantly male, cisgender, homosexual, single, and Catholic. A non-random, convenience sampling method was employed, and data were collected in the waiting room of a specialized HIV care clinic. Positive relationships (3 items, α = .740), negative emotions (anxiety, sadness, and anger; 3 items, α = .691), loneliness (1 item), and perceived happiness (1 item) were assessed using the PERMA-Profiler (Butler & Kern, 2016). Results revealed significant negative correlations between positive relationships and negative emotions: sadness (r = −.200, p < .002) and anger (r = −.167, p < .011). Additionally, a significant positive association was found between positive relationships and perceived happiness (r = .616, p < .001). No statistically significant correlations were observed between positive relationships and anxiety or loneliness. The role of positive relationships as a psychological resource for promoting well-being and reducing the risk of psychological distress among patients with HIV is discussed.​​This work was supported by UNAM-PAPIIT IN301225.