A systematic literature review was conducted to explore worldwide prevalence studies on student suicide, the risks and protective factors related to student suicide, and university-based interventions to combat it. The search of four major databases identified 60 studies published in peer-reviewed academic journals since 2015. Majority of these publications were from the United States, followed by China and the United Kingdom. Studies in South Africa and the African Continent as a whole were limited in terms of meeting the selection criteria of the review. The findings indicate that most of the publications ranged from describing suicide risk factors innate to students, such as their demographic and mental health features, to social and university stressors. Although the studies on protective factors were limited, several psychological, social, and behavioral elements to prevent student suicide were identified. The Three-
Step Theory of suicide was adopted to discuss the implications of the findings by presenting several campus based strategies to combat student suicides. The paper provides valuable lessons for universities across the globe to combat student suicides.