Drawing on the Conservation of Resources theory, this study investigates how information and communication technology (ICT) use at work relates to employees' perceptions of work meaningfulness, focusing on the mediating role of job insecurity and the moderating role of organizational participation. Data was collected from the seventh European Working Conditions Survey (Eurofound), across 37 European countries and 71,451 employees and analyzed using multilevel modelling. Results showed a dual pattern: ICT use was negatively related to job insecurity, which in turn was negatively related to meaningfulness, yielding a positive indirect effect of ICT on meaningfulness via job insecurity. At the same time, ICT showed a negative direct association with meaningfulness. Organizational Participation showed a moderating effect on the relationship between ICT use and Job Insecurity, indicating that higher levels of Organizational Participation strengthen the negative relationship between ICT use and Job Insecurity. These findings highlight ICT skills and participatory practices as key protective resources that reduce job insecurity and sustain work meaningfulness in the context of digital transformation.