Sexism in the workplace is experienced predominantly by women, and has been associated with both physical and adverse psychological consequences in multiple studies. While studies investigating sexual harassment in Ghanaian workplace have found high prevalence of this counterproductive workplace behavior, and found similar associations with poor psychological mental health outcomes, these studies have been conducted predominately by researchers in the business field. Clinical intervention recommendations for addressing this problem have therefore been underrepresented in the literature. This study sought to contribute to the literature by investigating whether locus of control moderated the relationship between workplace sexism and psychological ill-health in Ghanaian working women. 620 women employed in formal workplaces in Ghana participated in an online survey and completed self-report questionnaires that provided their experiences of workplace sexism; and identified their locus of control and psychological distress levels. The results showed that the majority of participants (73%) had experienced workplace sexism, and compared to those who reported not having any experiences with this behavior, had higher levels of psychological distress. Among participants who reported experiences with this counterproductive workplace behavior, those with internal loci of control had less symptoms of psychological distress: F (1,469) =214.46, p =. 000, which accounted for 58 % of the variance in psychological distress. The implications of this finding for clinical practice and policy are that in addition to providing trauma focused therapy for affected women, an adoption of a preventative approach for at risk women in the workplace, which focuses on building resilience through psychoeducation, as well as coping skills training which encourage social support seeking, assertiveness, and normalizing the limits of personal control should be included in workplace mental health outreach practices.