Introduction: Mindfulness has been widely recognized as a technique for reducing stress, regulating emotions, and improving well-being (Kabat-Zinn, 2003). Despite its extensive applications in clinical, organizational, and educational contexts, much of its contemporary practice has been secularized with limited attention to its Indian philosophical and cultural roots. This oversight limits a comprehensive understanding of its role as both a therapeutic method and a holistic life practice. Purpose: The present study aims to systematically review the existing literature to explore Indian philosophical and contemporary traditions, particularly Buddhist, Yogic, and Vedantic perspectives. The contemporary mindfulness practices acknowledge these roots, which may enrich global psychological applications. Method: This study was a systematic literature review that followed the PRISMA framework. As per the guidelines of the PRISMA model, the major databases include PsycINFO, PubMed, and Scopus publications between the period of 2000 and 2025. The inclusion criteria were comprised of peer-reviewed studies on mindfulness, particularly grounded in Indian philosophical roots or addressing cross-cultural adaptations. Non-peer-reviewed works and studies lacking clear references to cultural or psychological dimensions were excluded. From an initial pool of 50 studies, 23 have met the criteria. A narrative analysis was conducted, emphasizing key themes rather than detailed coding. Results: There were two main findings. First, mindfulness applications outside the world tend to overlook the ethical and cultural values that are part of Indian traditions while emphasizing psychological benefits like stress reduction and resilience (Shapiro et al., 2006). Second, therapies that incorporate these conceptual foundations exhibit longer-lasting results, especially in the areas of intercultural sensitivity, compassion, and holistic well-being. Conclusions: The findings highlight the significance of mindfulness within its Indian philosophical origins while engaging with its global applications. This intercultural perspective strengthens the scientific understanding of mindfulness-based practices that foster sustainable approaches to human well-being.