Introduction: Within the evolving paradigm of Industry 5.0, resilience is increasingly recognized as a strategic resource for promoting well-being and adaptability in high-tech manufacturing settings. However, existing assessment tools often lack the contextual sensitivity and fail to account for the specific demands of human-technology interaction. Purpose: This study introduces the Change Adaptation Resilience Evaluation Questionnaire for Industry 5.0 (CARE-QI 5.0), a novel multidimensional instrument designed to evaluate both individual and contextual dimensions of resilience among operators engaged in technologically advanced environments. Method: Using a sequential mixed-methods approach, the questionnaire was developed in four phases: literature review, expert content validation, focus groups and pilot administration in two Italian high-tech companies. The resulting instrument encompasses 88 items distributed across a global resilience score and two overarching domains: individual (i.e., change management and adaptation, self-efficacy, cognitive flexibility, and coping strategies) and contextual (i.e., perceived social support and organizational resilience) resilience, organized into 18 subscales. Results: A total of 64 operators (M = 46.11 years, SD = 10.71) took part in the study. Preliminary psychometric analyses indicated good internal consistency across most subscales (α = from 0.76 to 0.94). Key correlational findings (r ≥ .30, p < .05) highlighted the importance of support from significant others, colleagues, and the organization, as well as individual resources such as interpersonal self-efficacy and problem-oriented coping. Several additional subdimensions, particularly those related to skill-based resilience, cognitive flexibility, and change management and adaptation, also showed substantial relational density. Conversely, technology readiness, usage frequency, and job tenure appeared more peripheral within the network. Conclusions: CARE-QI 5.0 provides a theory-based, context-sensitive tool for enhancing both individual and organizational resilience and well-being, identifying strengths and vulnerabilities, and tailoring support accordingly in advanced manufacturing.