In our history sacred places and spaces were influenced by the types of ritual, the meanings of the ritual itself, and the kind of involvement or interaction between the faithful, the celebrant, the divine presence and the space. At different scales, from the urban to the architectural, the perceived space results from the interaction between ritual and construction. In the 20th century, the European and Italian experiences that led to the liturgical reform of the Vatican Council II changed the rituals, the way the faithful interacted during the liturgy, starting a process of architectural and spatial renewal. The sacred building takes on a different meaning in the urban context, a house among houses, and the internal space returns to being a place of assembly. The paper aims to investigate the relationship between ritual and sacred space with a focus on research and experiences that began in the 20th century and are not yet concluded.