The concept of "episteme" has had a phenomenal impact on the intellectual lexicon of Europe and the Western world. The Greek root behind such an impactful concept is prima facie a straightforward way of speaking about knowledge, yet the nuances of what knowledge means are manyfold, and the root naturally crosses genres and eras within Greek literature and available documentary sources. This paper explores the role of the root within the Greek Bible, in conversation with extra-biblical usages, to underline the specific nuances and translation strategies of the translators when they approached the idea in different contexts. It also shows some of the results of the lexical research in preparation of the corresponding HTLS article.