This paper aims at providing a reflection on the use of irony in the book of Judith. This figure of speech is employed at different levels in the biblical account. It is interesting to find that it allows the book to be related to Greek tragic production. My intent is to investigate the presence of this stylistic pattern in the biblical book, with particular reference to the dialogues between Judith and Holofernes. The aim will be to question the possible reasons for this relationship with Greek culture for a book set in a Hellenistic context.