O-129 - LONG-TERM SURVIVAL AFTER CAROTID ENDARTERECTOMY IN OCTOGENARIANS IN NORWAY 2015 - 2021

TOPIC:
Peripheral Occlusive Arterial Disease
AUTHORS:
Torsteinsen M. (Department of Vascular Surgery, St.Olavs Hospital. Department of Circulation and Imaging, NTNU. ~ Trondheim ~ Norway) , Seternes A. (Department of Vascular Surgery, St.Olavs Hospital. Department of Circulation and Imaging, NTNU. ~ Trondheim ~ Norway) , Altreuter M. (Department of Vascular Surgery, St.Olavs Hospital. Department of Circulation and Imaging, NTNU. ~ Trondheim ~ Norway)
Introduction:
Age over 80 years is regarded as a high-risk criterion in the treatment of carotid stenosis (1, 2). There is evidence that carotid endarterectomy (CEA) may be beneficial with lower risk of adverse cerebrovascular events than carotid artery stenting (CAS) in the octogenarian population (3-8). However, the overall goal of this treatment is to extend stroke-free survival combined with patient independence and quality of life. This is closely linked to long-term survival. This study reports national results for long-term survival after carotid endarterectomy in octogenarians in Norway for the 7-year period 2015 - 2021.
Methods:
We identified all patients undergoing CEA for carotid stenosis between 2015 and 2021 from the national registry. Carotid artery stenting (CAS) is rarely performed in Norway, hence only patients treated with CEA were included. 30-day mortality and long-term survival were calculated based on registry data. Estimates for mean and median survival and survival curves were calculated with Kaplan-Meier analysis. Statistical analysis was performed with SPSS.
Results:
We identified 474 patients aged 80 and above treated with CEA in the study period. Only a minority of these patients (n = 13) were treated for asymptomatic stenosis, the remaining 461 patients presented with symptomatic stenosis. In the same period, 2056 patients under the age of 80 years were treated with CEA. Median survival after CEA could not yet be determined in the study groups, but is over 6 years for patients over 80 years and much longer for patients under 80 years, as over 80 % in this group are alive after 6 years of observation. In the subgroup with patients 85 years and older, Kaplan-Meier estimate for median survival after CEA was 1779 days, which equals 4,8 years. Table 1 shows basic patients characteristics. Figure 1 shows survival for patients operated with CEA.
Conclusion:
Long-term survival in our study group supports the current policy of treating carotid disease in octogenarians. The figures suggest that there is no overtreatment in this age group at present, as most of the patients will benefit from the operation for many years.
References:
1. Centers for Medicare & Medicaid Services, Pub 100e03 Medicare National Coverage Determinations. Available at: http://www.cms.gov/Regulations-and-Guidance/Guidance/Transmittals/downloads/R115NCD.pdf 2. Naylor, A.R., J.-B. Ricco, G.J. de Borst, S. Debus, J. de Haro, A. Halliday, et al.: et al., Editor's Choice - Management of Atherosclerotic Carotid and Vertebral Artery Disease: 2017 Clinical Practice Guidelines of the European Society for Vascular Surgery (ESVS). Eur J Vasc Endovasc Surg, 2018. 55(1): p. 3-81. 3. Schermerhorn ML, Fokkema M, Goodney P, Dillavou ED, Jim J, Kenwood CT, et al.: The impact of Centers for Medicare and Medicaid Services high-risk criteria on outcome after carotid endarterectomy and carotid artery stenting in the SVS Vascular Registry. J Vasc Surg 2013;57:1318e24. 4. Howard G, Roubin GS, Jansen J, Halliday A, Fraedrich G, Eckstein H-H.: Association between age and risk of stroke or death from carotid endarterectomy and carotid stenting: a meta-analysis of pooled patient data from four randomised trials. Lancet 2016;387:1305e11. 5. Antoniou GA, Georgiadis GS, Georgakarakos EI, et.al. Meta-analysis and meta-regression analysis of outcomes of carotid endarterectomy and stenting in the elderly. JAMA Surg. 2013;148(12):1140-1152. Doi:10.1001/jamasurg.2013.4135 6. Voeks JH, Howard G, Roubin GS, et.al. Age and outcomes after carotid stenting and andarterectomy. The carotid revascularization endarterectomy versus stenting trial. Stroke. 2011;42:3484-3490. 7. Schmid S, Tsantilas P, Knappich C, et.al. Risk of inhospital stroke or death is associated with age but not sex in patients treated with carotid endarterectomy for asymptomatic or symptomatic carotid stenosis in routine practice: secondary data analysis of the nationwide German statutory assurance database from 2009 to 2014. J Am Heart Assoc. 2017;6:e004764. Doi:10.1161/JAHA.116.004764. 8. Texakalidis P, Chaitidis N, Giannopoulos S, et.al. Carotid revascularization in older adults: a systematic review and meta-analysis. World Neurosurg. 2019;126:656-663. https://doi.org/10.1016/j.wneu.2019.02.030
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