The early modern Republic of Letters is still often described through predominantly Western and Latin intellectual networks, while Eastern and Oriental Christian traditions appear only sporadically within its history. This paper approaches that larger problem through two concrete case studies—Athanasius Kircher and Johann Michael Wansleben—in order to examine how knowledge of Christian Egypt entered European scholarly circulation in the seventeenth century. Rather than offering a general survey of Coptic Christianity in early modern Europe, it focuses on two distinct but connected modes of mediation: philological systematization and manuscript-based travel scholarship. The first case study considers Kircher's engagement with Coptic in works such as the Prodromus Coptus and the Lingua Aegyptiaca Restituta, asking how he sought to classify, grammaticalize, and interpret Coptic within broader debates on sacred languages, biblical learning, and the legacy of ancient Egypt. The second turns to Wansleben, whose travels in Egypt, contact with local communities, and attention to libraries and manuscripts reveal a more material and contingent dimension of scholarly exchange. In his case, European knowledge of the Coptic East depended not only on erudite synthesis, but also on access, mediation, and lived encounter. By reading these two figures together, the paper argues that Coptic philology was shaped through both classificatory scholarship and fragile networks of travel, manuscript discovery, and local collaboration. In this way, it proposes a more precise understanding of how Christian Egypt became legible within the Republic of Letters and how Oriental Christian materials contributed to the formation of early modern Oriental learning.