The present paper, titled Rereading Paul the Neapolitan Deacon's Maria Egiziaca as a Spiritual Virago, analyzes the figure of Saint Mary of Egypt, whose treatment in Paul the Neapolitan Deacon's Latin source highlights numerous complexities. A sinful woman devoted to sex, Mary becomes, through asceticism, a new virgin, aided in her fight by the Virgin Mary. In this story of women who become other than themselves through other women, a man is also present: the monk Zosima, who, in the other hand, seems feminized upon encountering the now virile Mary, submitting to the wonders that make her an alter-Elijah and an alter-Christ, finally granting her sanctity. From this perspective, the study examines the gender inversions between Mary and Zosima through the lexicon of virilitas and infirmitas, categories that in Isidore of Seville's Etymologiae symbolically define relations between masculinity and femininity. Selected passages are analyzed where the linguistic relations between man (vir) and strength (vis) and woman (mulier) and softness (mollitia) are made explicit. From this perspective, the story can be read as the progressive transformation of the prostitute into a spiritual virago, achieved through her ascetic combat against sexuality and her physical transformation. Within the context of the historical-cultural construction of the feminine in Christian literature, Mary of Egypt is particularly significant: she not only surpasses some of the most recurrent clichés of female hagiography but also represents a notable case of redefining gender categories within Christian sanctity. The version attributed to Paul the Neapolitan Deacon emphasizes the physical and virile dimension of her asceticism, and this paper offers an interpretive perspective on her ambiguous status.