This paper examines the theme of the healing of body and soul in two works: On Human Nature by the Greek physician and philosopher Nemesius of Emesa (5th century) and the Prayer Book by the Armenian theologian and monk St.Gregory of Narek (10th century). Drawing on the traditions of ancient philosophy and science, as well as the writings of the Church Fathers, selected chapters or prayers articulate the relationship between soul and body from anthropological, philosophical, theological perspectives. Through an analysis of the spiritual experience of healing saints and saintly physicians, this study explores the intersection of medicine and religion, philosophy and medicine, highlighting their shared aim of restoring harmony between body and soul. First, the paper considers the scientific significance of these works. Both texts were of inestimable importance for medieval theological and philosophical thought. Their key anthropological premises were adopted by later authors and significantly influenced the development of medieval anthropological and medical traditions. On Human Nature, long regarded as a standard text, remained authoritative in the field of practical medicine and served as an anthropological manual in medieval monastic schools. Second, the paper examines the therapeutic function of prayer in the healing of body and soul. It argues that, from the Middle Ages to the present, healing has been understood as occurring through reliance on the divine Word, the harmonization of the inner and outer man, the practice of prayer, and the pursuit of Godlikeness. Owing to their spiritual and religious significance, these works became enduring manuals for monks, hermits, and lay believers alike. Some healing prayers from Gregory's Prayer Book were incorporated into medical compilations and read to the sick as life-giving remedies. They were also integrated into liturgical practice, further reinforcing the connection between spiritual devotion and therapeutic care.