Joachim of Fiore's theological thought is characteristically shaped by the prophetic language of Scripture. Prophecy, understood as a mode of interpreting history in the light of biblical revelation, constitutes a cornerstone of his approach not only to the sacred text but also to the interpretation of his own historical context. This use of biblical figurae, particularly those of apocalyptic significance, as a means of discerning the sapiential value of human history is especially evident in his treatment of the image of Babylon. Throughout his literary production—from the De prophetia ignota to the Expositio in Apocalysim—Joachim employed the apocalyptic figure of Babylon in order to address a range of contemporary historical crises: the conflict between Empire and Papacy, the strained relations between Rome and Constantinople, the fall of Jerusalem in 1187, and the rise of Saladin's power. This paper traces these various uses of the figure of Babylon in Joachim's works, demonstrating how it enabled him to articulate an interpretation of the major turning points of the late twelfth century that combined acute political concern with a broader reflection on the moral and religious significance of historical events.