This paper explores how the paradigm of integral ecology can inform and reshape open innovation and human-centric design. Bridging management and theological-philosophical traditions, we conceptualise integral ecology as a holistic lens that integrates environmental, social, cultural, and technological dimensions of innovation ecosystems. Drawing on a mixed-methods study with key ecosystem stakeholders, we investigate how integral ecology principles are translated into value propositions, governance mechanisms, and design practices. The paper advances an integrative framework for regenerative innovation, showing how integral ecology can provide the normative grounding needed to align collaborative innovation processes with justice, inclusiveness, and the common good.