This paper presents OIKOS Mediterraneo as a case study to explore how interdisciplinary collaboration can foster innovation models grounded in integral ecology. OIKOS acts as a living laboratory connecting academia, institutions, and civil society across the Mediterranean, promoting sustainable development, social inclusion, and ethical digital transformation. Through qualitative analysis and document review, the study illustrates how OIKOS integrates ecological, cultural, and technological dimensions to regenerate local systems and enhance territorial resilience. The case contributes to understanding how relational governance and human-centric innovation can serve as enablers of collective wellbeing and transformative sustainability.