In his essay Der Gegensatz (1925), Romano Guardini claims that God cannot be thought of as the unity of opposites, and that his theory of opposites differs radically from the notion of coincidentia oppositorum, which features in the work of Nicholas of Cusa. Cusa argues that although opposites coincide in God, God is beyond the coincidence of opposites. This paper will first explore the similarities and differences between Guardini's and Cusa's ideas of opposition, and evaluate whether and how Guardini's claim can be justified. Then, the difference between the two thinkers will be brought in relation with their views of catholicity. Cusa defined catholicity in terms of concord and consensus, while Guardini defined it as the totality of existence in the living concrete. Which view is more helpful for Catholic thought and practice today?