Our aim was the analysis of the clinical picture of primary hyperparathyroidism patients submitted to parathyroidectomy during the last 14 years.

Prospective study of all cases with primary hyperparathyroidism who underwent parathyroid surgery in our department from 1/1/2010 to 30/09/2023.

Women composed the vast majority (81.9%) of the total study group (n=342) (mean age: 56.6±7.4 years, range: 16-80 years). The diagnosis was single adenoma in 93%, primary parathyroid hyperplasia 5%, double adenoma 1.7% and cancer in 0.3%. The majority of cases presented with symptoms or complications (81%). They were related to the musculoskeletal system in 58.2%, urinary 35.4%, neurologic/psychiatric 10.2%, cardiovascular 5%, and gastrointestinal system in 3.2%, while 2% suffered from acute hyperparathyroid crisis and 0.6% from recurrent acute pancreatitis episodes. Mean symptoms duration was 4.3 years (range: 0.5-15 years). Osteopenia was identified in 23% and osteoporosis in 21%. Mean 24-hour urinary calcium was 340 mgr (range: 120-1173 mgr), while elevated levels were recorded in 53.8%. Additionally, 15.5% of the patients demonstrated severe urinary complications prior to parathyroidectomy.

Primary hyperparathyroidism patients submitted to parathyroidectomy very frequently present with symptoms and complications of the disease which are mostly related to the musculoskeletal or urinary system.